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The United States of America (U.S.A., United States, U.S., or America) is a nation composed of 50 states located on the North American continent.

Most of the events and characters from the Duke Nukem series are located in the United States. It is also home to the Earth Defense Forces (EDF), the military agency that employs Duke Nukem and defends all of Earth.

In Duke Nukem Forever, the President of the United States negotiates with a reborn Cycloid Emperor on behalf of all of Earth.

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