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This page refers to the Duke Nukem Forever enemy. For other uses, see here.

The Octabrain is an enemy in Duke Nukem Forever.


The Octabrain is a floating, medium-sized, octopus-shaped alien with three glowing eyes. One of its attacks consists of it tossing junk scattered throughout levels, such as barrels, at the player. It is also able to fire energy projectiles at the player from its brain. When stuck with a laser tripmine it will spin extremly fast and go kamikaze, trying to catch you in both the laser tripmine explosion and its own death-throes explosion.

Its deadliest ability is that it can catch any projectiles fired at it by the player and toss them back, such as Pipe bombs and rockets. The pre-release podcast has revealed that this will be exploited in at least one boss battle, where Octabrains will appear and will catch any projectiles that are fired at the boss. It kinda looks like he does not have skin on his head, so it shows his brain, but this appears to not be confirmed yet.

Combat Analysis

The Octobrain flies around while attacking via 2 methods. The first is to hover in the air and fire an energy blast at your location. Shooting the Octabrain while it readies the shot will disrupt it from firing. The second attack is to levitate and throw objects in the surrounding environment at the player. This occurs quite quickly, but this typically occurs when there is significant cover as well.

Upon death the Octabrain's body will fall and explode, dealing damage to everything around its corpse upon detonation. This will occur even if frozen, as the falling body will explode before a shatter may be possible (not sure if it is possible). This will not occur if the Octabrain is shrunk and stepped on, which is an effective weapon against them.

RPGs and Devastator shots fired around the Octabrain will be thrown back at the player, and it is unadvised to use those weapons. Pipe bombs will also be thrown back at the player, but enough time is given to detonate it before this occurs. Combined with the nature of catching projectiles, pipe bombs are an effective weapon due to the Octabrain pulling the pipebomb close.

Weapon effectivenesses
3 strikes
M1911 Pistol
9 shots
2 shots
20 shots
2 rockets
Pipe Bomb
Shrink Ray
Shrink Ray
1 blast
2 shots
Enforcer Gun
2 shots
9 rockets
Trip Mine
1 mine
Freeze Ray
45 shots
  • Note: The values given for the Shotgun and the explosive weapons are minimum values only.
  • Note: The values are expressed as in the Let's Rock difficulty setting. May change on higher/lower difficulty.
Duke Nukem Forever
Levels Main CampaignMultiplayer MapsSingleplayer Levels in The Doctor Who Cloned Me
Weapons AT Captain LaserAT LaserDevastatorDFGEnforcer GunExpanderFreeze RayGarter PistolImpregnaderM1911 PistolMachine Gun TurretMeleeN00b T00bPipe BombRailgunRipperRPGShotgunShrink RaySticky BombsTittyanaTrip Mine
Items BeerDuke StatueDuke VisionHolodukeJetpackSteroidsWhiskey
Enemies Alien DropshipAlien FighterAlien GunshipArea 51 Security RobotAssault CaptainAssault CommanderAssault TrooperBomb BallDuke CloneEnforcerOctababyOctabrainPigcopPregnatorRatTentacle
Bosses Alien QueenBattlelordCycloid EmperorDr. ProtonEnergy LeechGiant EnforcerMothershipOctaking
DLC Hail to the Icons Parody PackThe Doctor Who Cloned Me
Other CheatsDifficultyDuke Nukem (character)EgoMultiplayerQuotesScrapped Content