Drone may refer to:
- Sentry Drone, an explosive airborne enemy in Duke Nukem 3D
- Protector Drone, a flesh-colored enemy introduced in Duke Nukem 3D: Atomic Edition
- Drone, a green turret-mounted airborne enemy that was scrapped from Duke Nukem 3D
- Drone 2, a red turret-mounted airborne enemy that was scrapped from Duke Nukem 3D
- Underwater Drone, an aquatic variant of the Sentry Drone in Duke Nukem: Total Meltdown
- Bomb Ball, a floating spherical enemy in The Doctor Who Cloned Me